Comodo Auto-Sandbox -- as good as an anti-executable?

How well does Comodo Auto-Sandbox lock down a system?
I am running Comodo Firewall free version, without anti-virus component.
unrecognized applications are set to run virtually, and I have set location to : any
config is: Firewall Security
besides all that, I am manually running my browser in comodo sandbox.

Am I overdoing it?

Does turning on HIPS significantly improve protection?

Windows 10 x64
Webroot SecureAnywhere 2016
HitmanPro.Alert